Developing Drugs by Understanding Their Physiological Effects
Pharmacokinetics and pharmacodynamics are the study of how drugs behave in the body and how they reach their sites of action to exert their intended pharmacological activities. Drug discovery greatly benefits from the timely application of pharmacokinetics and pharmacodynamics to inform decision-making and solve practical problems.
Applying Pharmacokinetics and Pharmacodynamics to Drug Discovery bridges the gap between scientific concepts and practical industrial practices by applying these principles to every step of the drug discovery process. It begins with target identification and progresses through each subsequent decision point, including high-throughput screening, targeting to target, target optimization, and candidate selection. It provides a comprehensive guide to using various analytical tools, including modeling and artificial intelligence/machine learning, to minimize attrition, reduce costs, and more. The result is a valuable tool in developing smarter and more effective drug discovery processes.
Readers of Applying Pharmacokinetics and Pharmacodynamics to Drug Discovery will also find:
A work designed to make the scientific principles accessible to pharmaceutical scientists in a variety of fields, not just pharmacokinetic specialists or DMPK scientists.
Industrial examples, both positive and negative, demonstrate the principles of pharmacokinetics and pharmacodynamics in action.
Exercises throughout the book encourage holistic and integrated thinking.
Applying Pharmacokinetics and Pharmacodynamics to Drug Discovery is ideal for any researcher or professional involved in drug discovery and development, including medicinal chemists, biopharmaceutical scientists, clinicians, project leaders, and many others.
