This book is an original work dedicated to a crucial and contemporary topic in nephrology: the concept of organ crosstalk in the context of acute renal injury.
Acute kidney injury is a prevalent and serious syndrome, and despite advances in renal replacement therapy technology, related mortality rates have not significantly decreased over recent decades. Therefore, there is an urgent need for a new approach to provide effective treatment. Organ crosstalk may offer a promising perspective for achieving this goal, as it involves the early diagnosis and treatment of acute kidney injury.
The book offers a comprehensive review of the organ crosstalk concept within the context of acute kidney injury. It is divided into two parts, with the first part covering general subjects as an introduction to the crosstalk concept. These chapters provide an overview of important concepts such as biosemiotics, hormones, neurotransmitters, cytokines, signaling and adhesion molecules, organ intercommunication, and epigenetics. The second part of the book includes chapters dedicated to various forms of kidney crosstalk, including interactions with the brain, lung, heart, liver, gut, and placenta. Additionally, there is a chapter that explores the influence of renal replacement treatment on kidney crosstalk.
As acute kidney injury is a topic of significant interest to a wide range of healthcare professionals, this work will serve as a valuable resource for general practitioners, internal medicine physicians, geriatricians, nephrologists, critical care specialists, immunologists, as well as biologists and bioengineers.
