Adenoviral Vectors for Gene Therapy, Third Edition, is a comprehensive resource dedicated to adenovirus-based gene delivery vehicles, which are gaining recognition as crucial tools in the field of gene therapy. These innovative therapeutic agents hold remarkable promise for disease treatment, serving as platforms for both gene therapy and editing, as well as in oncology, positioning them as leaders in the realm of advanced gene-based therapies.
This thoroughly updated third edition delves into the fundamental biology of adenoviruses, shining a light on their potential applications in disease treatment. It covers essential topics such as the construction, propagation, and purification of adenoviral vectors, alongside the latest advancements in vectorology and the role of these vectors in preclinical animal models. Additionally, the book addresses the regulatory landscape surrounding human clinical gene therapy trials. Noteworthy new chapters include discussions on adenoviral vaccines for veterinary use, gene editing with adenoviruses, nonhuman primate adenoviruses, COVID-19 vaccine developments, diverse vaccine applications, and oncolytic adenoviruses for cancer immunization. This extensive array of information equips readers with a thorough understanding of the development and utilization of adenoviral vectors.
Key features of the third edition include:
– In-depth coverage of adenoviral biology, vector construction, propagation, and purification techniques.
– Insights into prevalent strategies for adenoviral vector development and advanced methods for their optimization.
– Demonstrations of noninvasive imaging techniques for tracking adenovirus-mediated gene transfer.
– Evaluations of the application of adenoviral vectors in models of animal diseases.
– An overview of FDA regulations applicable to human clinical trials.
This authoritative text serves as a valuable guide for researchers and professionals aiming to stay at the forefront of gene therapy and addiction research.
