Extracorporeal Life Support: The ELSO Red Book, 5th Edition” covers all aspects of the use of ECMO support therapies covering the use of ECMO in all patients from neonates to adults. The use of ECMO in patients with cardiac or respiratory dysfunction is covered in depth. The use of extracorporeal technologies in special circumstances such as sepsis, transplantation, and pregnancy among others. Additionally, details of program building, education, and economics are also covererd.